诚信声明我声明，所呈交的毕业论文（设计）是本人在老师指导下进行的研究工作及取得的研究成果。据我查证，除了文中特别加以标注和致谢的地方外，论文（设计)中不包含其他人已经发表或撰写过的研究成果，也不包含为获得其他教育机构的学位或证书而使用过的材料。我承诺，论文（设计）中的所有内容均真实、可信。毕业论文（设计）作者（签名）：年月日YL胶囊溶出度试验方法的初步研究【摘要】目的：建立YL胶囊溶出度试验方法，为其质量评价提供参考。方法：采用小杯法，模拟胃液的溶出介质为0.1molL盐酸溶液100mL,模拟肠液的溶出介质为pH-6.8的磷酸盐缓冲液100mL,转速50 rmin-,温度37±0.5℃进行溶出度试验，溶出液经孔径10um的滤膜滤过，用紫外分光光度计测定其600nm处的吸光度。结果：YL高浓度胶囊在胃液中无溶出，在肠液中完全溶出。结论：试验结果可为YL胶囊的质量评价提供参考，保证药物的质量。【关键词】YL胶囊；溶出度；比浊法：CCK-8;活菌数Preliminary Study on Dissolution Method of YL Capsules[Abstract]Objective:To establish a method of the determination of thedissolution of YL capsules,thus,to provide reference for its qualityevaluation.Methods:The small glass method was adopted for two differentdissolution media,the dissolution medium of simulated gastric fluid was 100mL of0.1mol/L hydrochloric acid solution,and the dissolution medium of simulatedintestinal fluid was 100mL of phosphate buffer with pH=6.8,the rotation speed was50rmin-1,and the temperature was 37+0.5C.The dissolution was filtered through afilter membrane with a pore size of 10 um,Its absorbance at 600 nm was determinedby an ultraviolet spectrophotometer.Results:The High concentration of YL capsulesdo not dissolve in gastric juice,while total dissolve in intestinal fluid.Conclusion:Theexperimental results can provide a reference for the quality evaluation of YL capsulesand ensure the quality of drugs.[Keywords]YL Capsules Dissolution Turbidimetric methodCell Counting Kit-8 Number of viable bacteria