诚信声明我声明，所呈交的毕业论文（设计）是本人在老师指导下进行的研究工作及取得的研究成果。据我查证，除了文中特别加以标注和致谢的地方外，论文(设计)中不包含其他人已经发表或撰写过的研究成果，也不包含为获得其他教育机构的学位或证书而使用过的材料。我承诺，论文（设计）中的所有内容均真实、可信。毕业论文（设计）作者（签名）：年月日自制药酒对高度白酒诱导的雌性小鼠肝损伤的作用【摘要】目的：探究自制药酒对于高度白酒诱导的雌性小鼠肝损伤的作用。方法：通过每12h灌胃高度白酒或药酒，同时日常给予低度酒精饮料的方法建立雌性小鼠的肝损伤模型，同等条件下，边造模边给药，探究自制药酒对于高度白酒诱导的雌性小鼠肝损伤的作用。对比给药组（药酒组、药酒+二锅头组）、模型组（基酒组、二锅头组）和空白组小鼠肝脏系数，检测小鼠血清谷草转氨酶(GOT)、谷丙转氨酶(GPT)的含量，最后分析肝脏组织HE染色切片形态变化，综合得出结论。结果：实验三个月后，与空白组相比，模型组和药酒+二锅头组的肝脏系数均显著升高，药酒组的肝脏系数无显著性差异：模型组血清中的GOT和GPT含量均显著性增加，HE染色切片显示模型组肝损伤严重，而药酒组肝损伤情况能够有所好转。结论：成功建立酒精诱导雌性小鼠肝损伤模型。自制药酒具有减轻高度白酒诱导的雌性小鼠肝损伤的作用。【关键词】药酒：肝损伤模型：酒精性肝损伤：雌性小鼠Effects of self-made drug-alcohol on liver injury induced byhigh alcohol in female mice[Abstract]Objective:To explore the effect of self-made drug-alcohol onliver injury induced by high alcohol in female mice.Methods:The model of liverinjury in female mice was established by intragastric administration of high-alcohol ormedicinal liquor every 12 hours and daily administration of low-alcohol beverage,under the same conditions,the effect of self-made medicinal drug-alcohol on the liverinjury induced by high-alcohol in female mice was investigated.Contrast to medicinegroup(drug-alcohol group,drug-alcohol add Erguotou group),model group(basicgroup,Erguotou group)and blank group mice liver coefficient,and test the mice forserum Aspartate aminotransferase(GOT),Alanine aminotransferase(GPT)level.Finally,by analyzing the morphological changes of HE staining sections of livertissue,the conclusion could be drawn.Results:Experiment after three months,compared with the blank group,the liver coefficient of the model group and the drug-alcohol add Erguotou group increased significantly,but there was no significantdifference in the drug-alcohol group.The content of GOT and GPT in serum of modelgroup increased significantly.HE staining sections show that the liver injury in modelgroup was serious,while in medicated wine group liver damage situation can beimproved.Conclusion:The model of alcohol-induced liver injury in female mice wasestablished successfully.The self-made drug-alcohol can alleviate the liver injuryinduced by high-alcohol in female mice.[Keywords]Medicinal wine Model of liver injury Alcoholic liver damage Femalemice