诚信声明我声明，所呈交的毕业论文（设计）是本人在老师指导下进行的研究工作及取得的研究成果。据我查证，除了文中特别加以标注和致谢的地方外，论文（设计）中不包含其他人已经发表或撰写过的研究成果，也不包含为获得其他教育机构的学位或证书而使用过的材料。我承诺，论文（设计）中的所有内容均真实、可信。毕业论文（设计）作者（签名）：年月日硫唑嘌呤片的制备及体外溶出度评价【摘要】目的：根据参比制剂的处方来制备硫唑嘌呤片(Azathioprinetablets),根据中国药典测定其质量标准并考察硫唑嘌呤片的体外溶出行为，为硫唑嘌呤片的质量控制提供参考。方法：采用粉末直压的工艺压片，自制硫唑嘌呤片剂(50mg规格)：此外，采用高效液相色谱方法测定自制硫唑嘌呤片的含量分数：建立紫外分光光度法测定硫唑嘌呤片的溶出度：结果：高效液相色谱方法测定自制硫唑嘌岭片中药物质量分数达到中国药典的要求。自制的硫唑嘌呤片与参比制剂溶出基本一致，且自制片与参比制剂溶出曲线较为相似。该方法所测得硫唑嘌呤片的溶出度与其片剂相关性良好。结论：硫唑嘌呤片体外溶出度测定方法简单、方便、准确度高：自制硫唑嘌呤片与参比制剂的体外溶出行为较为相似。【关键词】硫唑嘌呤片：体外溶出度：仿制药：质量分析Preparation and in vitro dissolution evaluation ofazathioprine tablets[Abstract]Objective:Azathioprine tablets are prepared according to theprescription of reference preparations.The quality standards of azathioprine tabletsare determined according to the Chinese Pharmacopoeia and their dissolutionbehavior in vitro is investigated,providing reference for quality control ofazathioprine tablets.Method:zathioprine tablets(50mg specification)were preparedby direct pressing of powder.In addition,the content fraction of self-madeazathioprine tablets was determined by HPLC.The dissolution of azathioprine tabletswas determined by ultraviolet spectrophotometry.Result:The determination ofquality fraction of self-made azathioprine tablets by high performance liquidchromatography met the requirements of Chinese Pharmacopoeia.The dissolutioncurve of self-made azathioprine tablets and reference preparation was similar.Thedissolution rate of azathioprine tablets measured by this method has good correlationwith its tablets.Conclusion:The method of in vitro dissolution of azathioprine tabletsis simple,convenient and accurate.The dissolution behavior of self-madeazathioprine tablets and reference preparations was similar in vitro.[Keywords]Azathioprine tablets In vitro dissolution Generic drugsQuality analysis